IDF21-0279 Association between Renal Tubulointerstitial Inflammatory Cells Infiltration and Renal Outcome in Diabetic Nephropathy

Background: Diabetic nephropathy (DN) continues to be the leading cause of end-stage renal disease (ESRD) worldwide, and increased amount evidence supports that inflammation plays an important role in DN progression. Aim: Therefore, we aimed explore relationships between tubulointerstitial inflammatory cells infiltration kidney prognosis patients. Method: A total 384 Chinese participants with type 2 diabetes (T2D) biopsy-confirmed January 2008 July 2019 were enrolled. Cox proportional-hazards regression analysis was used for analyzing association outcome including plasma cells, lymphocytes, monocytes, neutrophils eosinophils. Single-cell RNA sequencing human conducted compare gene expression healthy subjects. Results: Among five kinds only presence found independently associated incident ESRD patients after adjusting model 1 (age, sex, baseline 24-hour proteinuria, estimated glomerular filtration rate, glycated hemoglobin, triglyceride, hazard ratio (HR)=1.44, p=0.037) (parameters plus complement3 Deposit+ glomeruli, class, interstitial inflammation, fibrosis tubular atrophy (IFTA) as well arteriolar hyalinosis, HR=1.44, p=0.047). Moreover, percentages samples by single-cell higher compared control. RPS26, HLA-DRB5, HLA-DQA2, MT-CO2, MT-CO3, CD52, LINC01781, SH3BGRL3, C8orf59, MZT2B up regulated cell group SLC20A1, RGS2, MIDN, TLE3, HLA-DRB1, SKIL, MZB1, ZFP36, HSPA1B HERPUD1 down group. Discussion: The independent prognostic risk factor future T2D DN.